Ontology highlight
ABSTRACT:
SUBMITTER: Kirkby NS
PROVIDER: S-EPMC3491520 | biostudies-other | 2012 Oct
REPOSITORIES: biostudies-other
Kirkby Nicholas S NS Lundberg Martina H MH Harrington Louise S LS Leadbeater Philip D M PD Milne Ginger L GL Potter Claire M F CM Al-Yamani Malak M Adeyemi Oladipupo O Warner Timothy D TD Mitchell Jane A JA
Proceedings of the National Academy of Sciences of the United States of America 20121008 43
Prostacyclin is an antithrombotic hormone produced by the endothelium, whose production is dependent on cyclooxygenase (COX) enzymes of which two isoforms exist. It is widely believed that COX-2 drives prostacyclin production and that this explains the cardiovascular toxicity associated with COX-2 inhibition, yet the evidence for this relies on indirect evidence from urinary metabolites. Here we have used a range of experimental approaches to explore which isoform drives the production of prosta ...[more]