Ontology highlight
ABSTRACT:
SUBMITTER: Urban N
PROVIDER: S-EPMC3493821 | biostudies-other | 2012 Nov
REPOSITORIES: biostudies-other
Urban Nicole N Thorpe Jason J Karlan Beth Y BY McIntosh Martin W MW Palomares Melanie R MR Daly Mary B MB Paley Pamela P Drescher Charles W CW
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20120907 11
<h4>Background</h4>Human epididymis protein 4 (HE4) is approved for clinical use with CA125 to predict epithelial ovarian cancer in women with a pelvic mass or in remission after chemotherapy. Previously reported reference ranges for HE4 are inconsistent.<h4>Methods</h4>We report positivity thresholds yielding 90%, 95%, 98%, and 99% specificity for age-defined populations of healthy women for HE4, CA125, and Risk of Ovarian Malignancy Algorithm (ROMA), a weighted average of HE4 and CA125. HE4 an ...[more]