A complex of ?6 integrin and E-cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6.
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ABSTRACT:
SUBMITTER: Marchio S
PROVIDER: S-EPMC3494873 | biostudies-other | 2012 Nov
REPOSITORIES: biostudies-other
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A complex of α6 integrin and E-cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6.
Marchiò Serena S Soster Marco M Cardaci Sabrina S Muratore Andrea A Bartolini Alice A Barone Vanessa V Ribero Dario D Monti Maria M Bovino Paola P Sun Jessica J Giavazzi Raffaella R Asioli Sofia S Cassoni Paola P Capussotti Lorenzo L Pucci Piero P Bugatti Antonella A Rusnati Marco M Pasqualini Renata R Arap Wadih W Bussolino Federico F
EMBO molecular medicine 20121016 11
Homing of colorectal cancer (CRC) cells to the liver is a non-random process driven by a crosstalk between tumour cells and components of the host tissue. Here we report the isolation of a liver metastasis-specific peptide ligand (CGIYRLRSC) that binds a complex of E-cadherin and α(6) integrin on the surface of CRC cells. We identify angiopoietin-like 6 protein as a peptide-mimicked natural ligand enriched in hepatic blood vessels of CRC patients. We demonstrate that an interaction between hepat ...[more]
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