Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen HM
PROVIDER: S-EPMC3494885 | biostudies-other | 2012 Nov
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20121022 45
Voltage-gated sodium (Na(V)) and potassium (K(V)) channels are critical components of neuronal action potential generation and propagation. Here, we report that Na(V)β1 encoded by SCN1b, an integral subunit of Na(V) channels, coassembles with and modulates the biophysical properties of K(V)1 and K(V)7 channels, but not K(V)3 channels, in an isoform-specific manner. Distinct domains of Na(V)β1 are involved in modulation of the different K(V) channels. Studies with channel chimeras demonstrate tha ...[more]