Ontology highlight
ABSTRACT:
SUBMITTER: Lopez-Girona A
PROVIDER: S-EPMC3496085 | biostudies-other | 2012 Nov
REPOSITORIES: biostudies-other
Lopez-Girona A A Mendy D D Ito T T Miller K K Gandhi A K AK Kang J J Karasawa S S Carmel G G Jackson P P Abbasian M M Mahmoudi A A Cathers B B Rychak E E Gaidarova S S Chen R R Schafer P H PH Handa H H Daniel T O TO Evans J F JF Chopra R R
Leukemia 20120503 11
Thalidomide and the immunomodulatory drug, lenalidomide, are therapeutically active in hematological malignancies. The ubiquitously expressed E3 ligase protein cereblon (CRBN) has been identified as the primary teratogenic target of thalidomide. Our studies demonstrate that thalidomide, lenalidomide and another immunomodulatory drug, pomalidomide, bound endogenous CRBN and recombinant CRBN-DNA damage binding protein-1 (DDB1) complexes. CRBN mediated antiproliferative activities of lenalidomide a ...[more]