Ontology highlight
ABSTRACT:
SUBMITTER: Nebert DW
PROVIDER: S-EPMC3500200 | biostudies-other | 2004 Nov
REPOSITORIES: biostudies-other
Nebert Daniel W DW Vasiliou Vasilis V
Human genomics 20041101 6
The glutathione S-transferase (GST) gene family encodes genes that are critical for certain life processes, as well as for detoxication and toxification mechanisms, via conjugation of reduced glutathione (GSH) with numerous substrates such as pharmaceuticals and environmental pollutants. The GST genes are upregulated in response to oxidative stress and are inexplicably overexpressed in many tumours, leading to problems during cancer chemotherapy. An analysis of the GST gene family in the Human G ...[more]