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Continuous sheath-free magnetic separation of particles in a U-shaped microchannel.


ABSTRACT: Particle separation is important to many chemical and biomedical applications. Magnetic field-induced particle separation is simple, cheap, and free of fluid heating issues that accompany electric, acoustic, and optical methods. We develop herein a novel microfluidic approach to continuous sheath-free magnetic separation of particles. This approach exploits the negative or positive magnetophoretic deflection to focus and separate particles in the two branches of a U-shaped microchannel, respectively. It is applicable to both magnetic and diamagnetic particle separations, and is demonstrated through the sorting of 5 μm and 15 μm polystyrene particles suspended in a dilute ferrofluid.

SUBMITTER: Liang L 

PROVIDER: S-EPMC3500308 | biostudies-other | 2012

REPOSITORIES: biostudies-other

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