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High normal plasma triglycerides are associated with preserved cognitive function in Chinese oldest-old.

ABSTRACT: to explore the relationship between blood lipids/lipoproteins and cognitive function in the Chinese oldest-old.multivariate statistical analysis using cross-sectional data.community-based setting in longevity areas in China.eight hundred and thirty-six subjects aged 80 and older were included in the sample.plasma total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, blood pressure and fasting plasma glucose were measured and information about demographics and lifestyle was collected. Cognitive status was assessed using the Mini-Mental State Examination (MMSE).cumulative logit model analysis showed that triglyceride was significantly negatively associated with cognitive impairment. By general linear modelling, there was a significant linear trend of MMSE scores with the level of triglyceride, but not with levels of cholesterol after adjustment. The odds ratio (OR) of cognitive impairment (MMSE score < 18) was significantly reduced for the highest quartile of plasma triglyceride concentration (OR: 0.52, 95% CI: 0.33-0.84), but not for the second or third quartile, compared with the lowest quartile (adjusted models). There were no significant associations between cognitive impairment and cholesterol.we concluded that high normal plasma triglyceride was associated with preservation of cognitive function while lower concentrations were not in the Chinese oldest-old.

SUBMITTER: Yin ZX

PROVIDER: S-EPMC3500861 | biostudies-other | 2012 Sep

REPOSITORIES: biostudies-other

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High normal plasma triglycerides are associated with preserved cognitive function in Chinese oldest-old.

Yin Zhao-Xue ZX Shi Xiao-Ming XM Kraus Virginia B VB Fitzgerald Simon M SM Qian Han-Zhu HZ Xu Jian-Wei JW Zhai Yi Y Sereny Melanie D MD Zeng Yi Y

Age and ageing 20120323 5

<h4>Objective</h4>to explore the relationship between blood lipids/lipoproteins and cognitive function in the Chinese oldest-old.<h4>Design</h4>multivariate statistical analysis using cross-sectional data.<h4>Setting</h4>community-based setting in longevity areas in China.<h4>Subjects</h4>eight hundred and thirty-six subjects aged 80 and older were included in the sample.<h4>Methods</h4>plasma total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholest ...[more]

PMID: 22447910

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Project description:ObjectivesCurrently, most treatment guidelines suggest lowering hypertriglyceridemia of any severity, even in elderly individuals. However associations of serum triglycerides (TGs) with adverse health and mortality risk decrease with age, it remains unclear among the oldest old (aged 80 years and older). The study was to investigate the relationship of serum TG concentrations with cognitive function, activities of daily living (ADLs), frailty, and mortality among the oldest old in a prospective cohort study.DesignLongitudinal prospective cohort study.SettingCommunity-based setting in longevity areas in China.ParticipantsA total of 930 (mean age = 94.0 years) Chinese oldest old.MeasurementsThe TG concentrations were measured at baseline survey in 2009. Cognitive function, ADLs, frailty, and mortality were determined over 5 years of follow-up. Cox proportional hazards models and competing risk models were performed to explore the association, adjusting for potential confounders.ResultsEach 1-mmol/L increase in TGs was associated with a nearly 20% lower risk of cognitive decline, ADL decline, and frailty aggravation during the 5 years of follow-up. Consistently, higher TGs (each 1 mmol/L) was associated with lower 5-year all-cause mortality after fully adjustment (hazard ratio [HR] = 0.79; 95% confidence interval [CI] = 0.69-0.89). Nonelevated TG concentrations (less than 2.26 mmol/L) were associated with higher mortality risk (HR = 1.72; 95% CI = 1.22-2.44), relative to TGs of 2.26 mmol/L or more. We observed similar results regarding TG concentrations and mortality in 1-year lag analysis and when excluding participants with identified chronic disease.ConclusionIn the oldest old, a higher concentration of TGs was associated with a lower risk of cognitive decline, ADL decline, frailty aggravation, and mortality. This paradox suggests the clinical importance of revisiting the concept of "the lower the better" for the oldest old. J Am Geriatr Soc 67:741-748, 2019.

Project description:BackgroundInflammatory markers, such as high sensitivity C-reactive protein (hs-CRP), and cognitive impairment (CI) are associated with mortality; CRP is related to the deterioration of CI. However, it is still unknown whether these two indices predict mortality independent of each other. Furthermore, their joint effect on all-cause mortality has not been well established, especially in oldest-old adults.MethodsBased on data from the 2012 wave of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), we included 1447 oldest-old adults (mean age 84.7 years and 58.7% were female, weighted) with information on hs-CRP (stratified by a cutoff value of 3.0 mg/L) and cognition (quantified by Mini-Mental Status Examination (MMSE) scored according to the personal educational level) at baseline. Mortality was assessed in followed 2014 and 2017 waves. Cox proportional hazards regression models were used, with adjustment for hs-CRP and cognition (mutually controlled) and several traditional mortality risk factors.ResultsDuring a median follow-up period of 32.8 months (Q1-Q3, 9.7-59.0 months), 826 participants died. Hs-CRP [HR > 3.0 mg/L vs ≤ 3.0 mg/L: 1.64 (95% CI, 1.17, 2.30)] and cognition [HR CI vs normal: 2.30 (95% CI, 1.64, 3.21)] each was independent predictor of all-cause mortality, even after accounting for each other and other covariates. Monotonic and positive associations were observed in combined analyses, in which the highest mortality risk was obtained in elders with both high hs-CRP> 3.0 mg/L and CI [HR: 3.56 (95% CI, 2.35, 5.38)].The combined effects were stronger in male and younger oldest-old (aged 80-89 years).ConclusionHigh hs-CRP and CI, both individually and jointly, were associated with increased all-cause mortality risks in Chinese oldest-old. Intervention strategies for preventing inflammation and maintaining adequate cognitive function may be more important in male and younger oldest-old for reducing mortality risk.

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High normal plasma triglycerides are associated with preserved cognitive function in Chinese oldest-old.

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High normal plasma triglycerides are associated with preserved cognitive function in Chinese oldest-old.

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