Ontology highlight
ABSTRACT:
SUBMITTER: Braga TT
PROVIDER: S-EPMC3510298 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Braga Tarcio Teodoro TT Correa-Costa Matheus M Guise Yuri Felipe Souza YF Castoldi Angela A de Oliveira Cassiano Donizetti CD Hyane Meire Ioshie MI Cenedeze Marcos Antonio MA Teixeira Simone Aparecida SA Muscara Marcelo Nicolas MN Perez Katia Regina KR Cuccovia Iolanda Midea IM Pacheco-Silva Alvaro A Gonçalves Giselle Martins GM Camara Niels Olsen Saraiva NO
Molecular medicine (Cambridge, Mass.) 20121024
Inflammation contributes to the pathogenesis of chronic kidney disease (CKD). Molecules released by the inflamed injured tissue can activate toll-like receptors (TLRs), thereby modulating macrophage and CD4(+) T-cell activity. We propose that in renal fibrogenesis, M2 macrophages are recruited and activated in a T helper subset 2 cell (T(H)2)-prone inflammatory milieu in a MyD88-dependent manner. Mice submitted to unilateral ureteral ligation (UUO) demonstrated an increase in macrophage infiltra ...[more]