Ontology highlight
ABSTRACT:
SUBMITTER: Vargas-Rodriguez Rdel C
PROVIDER: S-EPMC3516255 | biostudies-other | 2012 Nov
REPOSITORIES: biostudies-other
Vargas-Rodríguez Rosa del Carmen Miluska Rdel C da Silva Bastos Melissa M Menezes Maria José MJ Orjuela-Sánchez Pamela P Ferreira Marcelo U MU
The American journal of tropical medicine and hygiene 20120904 5
Emerging resistance to chloroquine (CQ) poses a major challenge for Plasmodium vivax malaria control, and nucleotide substitutions and copy number variation in the P. vivax multidrug resistance 1 (pvmdr-1) locus, which encodes a digestive vacuole membrane transporter, may modulate this phenotype. We describe patterns of genetic variation in pvmdr-1 alleles from Acre and Amazonas in northwestern Brazil, and compare then with those reported in other malaria-endemic regions. The pvmdr-1 mutation Y9 ...[more]