Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC3520067 | biostudies-other | 2012 Feb
REPOSITORIES: biostudies-other
Li Xiang X Foley Emily A EA Molloy Kelly R KR Li Yinyin Y Chait Brian T BT Kapoor Tarun M TM
Journal of the American Chemical Society 20120124 4
Post-translational modifications (PTMs) (e.g., acetylation, methylation, and phosphorylation) play crucial roles in regulating the diverse protein-protein interactions involved in essentially every cellular process. While significant progress has been made to detect PTMs, profiling protein-protein interactions mediated by these PTMs remains a challenge. Here, we report a method that combines a photo-cross-linking strategy with stable isotope labeling in cell culture (SILAC)-based quantitative ma ...[more]