Expression and significance of histone H3K27 demethylases in renal cell carcinoma.
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ABSTRACT:
SUBMITTER: Shen Y
PROVIDER: S-EPMC3520868 | biostudies-other | 2012 Oct
REPOSITORIES: biostudies-other
Publications
Expression and significance of histone H3K27 demethylases in renal cell carcinoma.
Shen Yongqing Y Guo Xiaoqiang X Wang Yuejia Y Qiu Wei W Chang Yanzhong Y Zhang Aili A Duan Xianglin X
BMC cancer 20121012
<h4>Background</h4>The histone H3K27 demethylases UTX and JMJD3 are important regulatory factors that modulate gene expression by altering the physical state of chromatin. Previous studies have indicated an abnormal H3K27 methylation status in carcinogenesis. We therefore investigated the expression patterns of UTX and JMJD3 in renal cell carcinoma (RCC) and their roles in cancer development.<h4>Methods</h4>The mRNA expression levels of the UTX and JMJD3 genes were determined in cancer tissues a ...[more]
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