Ontology highlight
ABSTRACT:
SUBMITTER: Khodosevich K
PROVIDER: S-EPMC3523819 | biostudies-other | 2012 Dec
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20121119 49
Connexins have been implicated in the regulation of precursor cell migration and proliferation during embryonic development of the mammalian brain. However, their function in postnatal neurogenesis is unclear. Here we demonstrate that connexin (Cx) 45 is expressed in transit-amplifying cells and neuroblasts in the postnatal subventricular zone (SVZ) and modulated the proliferation of SVZ-derived precursor cells in vivo. Thus, overexpression of Cx45 by retroviral injections increased the prolifer ...[more]