Unknown

Dataset Information

0

Vitamin D status and cause-specific mortality: a general population study.


ABSTRACT: BACKGROUND: Vitamin D deficiency is associated with an increased risk of all-cause mortality in observational studies. The specific causes of death underlying this association lack clarity. We investigated the association between vitamin D status and cause-specific mortality. METHODS: We included a total of 9,146 individuals from the two population-based studies, Monica10 and Inter99, conducted in 1993-94 and 1999-2001, respectively. Vitamin D status was assessed as serum 25-hydroxyvitamin D. Information on causes of death was obtained from The Danish Register of Causes of Death until 31 December 2009. There were a total of 832 deaths (median follow-up 10.3 years). RESULTS: Multivariable Cox regression analyses with age as underlying time axis and vitamin D quartiles showed significant associations between vitamin D status and death caused by diseases of the respiratory system, the digestive system, and endocrine, nutritional and metabolic diseases with hazard ratios (HRs) 0.26 (p(trend) = 0.0042), 0.28 (p(trend) = 0.0040), and 0.21 (p(trend) = 0.035), respectively, for the fourth vitamin D quartile compared to the first. We found non-significantly lower HRs for death caused by mental and behavioural diseases and diseases of the nervous system, but no association between vitamin D status and death caused by neoplasms or diseases of the circulatory system. CONCLUSION: The associations of vitamin D status and cause-specific mortality suggest that we also look elsewhere (than to cardiovascular disease and cancer) to explain the inverse association between vitamin D status and mortality.

SUBMITTER: Skaaby T 

PROVIDER: S-EPMC3527503 | biostudies-other | 2012

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC5052338 | biostudies-other
| S-EPMC6774516 | biostudies-literature
| S-EPMC8944012 | biostudies-literature
| S-EPMC3942472 | biostudies-other
| S-EPMC6581547 | biostudies-literature
| S-EPMC6011585 | biostudies-literature
| S-EPMC8472743 | biostudies-literature
| S-EPMC6991261 | biostudies-literature
| S-EPMC7726887 | biostudies-literature
| S-EPMC4220129 | biostudies-literature