Ontology highlight
ABSTRACT:
SUBMITTER: Fratta P
PROVIDER: S-EPMC3527825 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Fratta Pietro P Fratta Pietro P Mizielinska Sarah S Nicoll Andrew J AJ Zloh Mire M Fisher Elizabeth M C EM Parkinson Gary G Isaacs Adrian M AM
Scientific reports 20121221
Large expansions of a non-coding GGGGCC-repeat in the first intron of the C9orf72 gene are a common cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). G-rich sequences have a propensity for forming highly stable quadruplex structures in both RNA and DNA termed G-quadruplexes. G-quadruplexes have been shown to be involved in a range of processes including telomere stability and RNA transcription, splicing, translation and transport. Here we show using NMR and CD ...[more]