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Aromatic-aromatic interactions in structures of proteins and protein-DNA complexes: a study based on orientation and distance.

ABSTRACT: Interactions between the aromatic amino acid residues have a significant influence on the protein structures and protein-DNA complexes. These interactions individually provide little stability to the structure; however, together they contribute significantly to the conformational stability of the protein structure. In this study, we focus on the four aromatic amino acid residues and their interactions with one another and their individual interactions with the four nucleotide bases. These are analyzed in order to determine the extent to which their orientation and the number of interactions contribute to the protein and protein-DNA complex structures.

SUBMITTER: Anjana R 

PROVIDER: S-EPMC3530875 | biostudies-other | 2012

REPOSITORIES: biostudies-other

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Aromatic-aromatic interactions in structures of proteins and protein-DNA complexes: a study based on orientation and distance.

Anjana Ramnath R   Vaishnavi Marthandan Kirti MK   Sherlin Durairaj D   Kumar Surapaneni Pavan SP   Naveen Kora K   Kanth Pasam Sandeep PS   Sekar Kanagaraj K  

Bioinformation 20121208 24

Interactions between the aromatic amino acid residues have a significant influence on the protein structures and protein-DNA complexes. These interactions individually provide little stability to the structure; however, together they contribute significantly to the conformational stability of the protein structure. In this study, we focus on the four aromatic amino acid residues and their interactions with one another and their individual interactions with the four nucleotide bases. These are an  ...[more]