Ontology highlight
ABSTRACT:
SUBMITTER: Oromendia AB
PROVIDER: S-EPMC3533075 | biostudies-other | 2012 Dec
REPOSITORIES: biostudies-other
Oromendia Ana B AB Dodgson Stacie E SE Amon Angelika A
Genes & development 20121207 24
Gains or losses of entire chromosomes lead to aneuploidy, a condition tolerated poorly in all eukaryotes analyzed to date. How aneuploidy affects organismal and cellular physiology is poorly understood. We found that aneuploid budding yeast cells are under proteotoxic stress. Aneuploid strains are prone to aggregation of endogenous proteins as well as of ectopically expressed hard-to-fold proteins such as those containing polyglutamine (polyQ) stretches. Protein aggregate formation in aneuploid ...[more]