Strain-specific hyperkyphosis and megaesophagus in Add1 null mice.
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ABSTRACT:
SUBMITTER: Robledo RF
PROVIDER: S-EPMC3534825 | biostudies-other | 2012 Dec
REPOSITORIES: biostudies-other
Publications
Strain-specific hyperkyphosis and megaesophagus in Add1 null mice.
Robledo Raymond F RF Seburn Kevin L KL Nicholson Anthony A Peters Luanne L LL
Genesis (New York, N.Y. : 2000) 20120912 12
The three adducin proteins (α, β, and γ) share extensive sequence, structural, and functional homology. Heterodimers of α- and β-adducin are vital components of the red cell membrane skeleton, which is required to maintain red cell elasticity and structural integrity. In addition to anemia, targeted deletion of the α-adducin gene (Add1) reveals unexpected, strain-dependent non-erythroid phenotypes. On an inbred 129 genetic background, Add1 null mice show abnormal inward curvature of the cervicot ...[more]
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