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TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis.


ABSTRACT: This paper provides the reader with an overview of our current knowledge of hypothalamic-pituitary-thyroid feedback from a cybernetic standpoint. Over the past decades we have gained a plethora of information from biochemical, clinical, and epidemiological investigation, especially on the role of TSH and other thyrotropic agonists as critical components of this complex relationship. Integrating these data into a systems perspective delivers new insights into static and dynamic behaviour of thyroid homeostasis. Explicit usage of this information with mathematical methods promises to deliver a better understanding of thyrotropic feedback control and new options for personalised diagnosis of thyroid dysfunction and targeted therapy, also by permitting a new perspective on the conundrum of the TSH reference range.

SUBMITTER: Dietrich JW 

PROVIDER: S-EPMC3544290 | biostudies-other | 2012

REPOSITORIES: biostudies-other

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TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis.

Dietrich Johannes W JW   Landgrafe Gabi G   Fotiadou Elisavet H EH  

Journal of thyroid research 20121230


This paper provides the reader with an overview of our current knowledge of hypothalamic-pituitary-thyroid feedback from a cybernetic standpoint. Over the past decades we have gained a plethora of information from biochemical, clinical, and epidemiological investigation, especially on the role of TSH and other thyrotropic agonists as critical components of this complex relationship. Integrating these data into a systems perspective delivers new insights into static and dynamic behaviour of thyro  ...[more]

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