Ontology highlight
ABSTRACT:
SUBMITTER: Tong MH
PROVIDER: S-EPMC3545805 | biostudies-other | 2013 Jan
REPOSITORIES: biostudies-other
Tong Ming-Han MH Yang Qi-En QE Davis Jeffrey C JC Griswold Michael D MD
Proceedings of the National Academy of Sciences of the United States of America 20121224 2
Retinoic acid (RA), an active vitamin A derivative, is essential for mammalian spermatogenesis. Genetic studies have revealed that oxidation of vitamin A to retinal by retinol dehydrogenase 10 (RDH10) is critical for embryonic RA biosynthesis. However, physiological roles of RDH10 in postnatal RA synthesis remain unclear, given that Rdh10 loss-of-function mutations lead to early embryonic lethality. We conducted in vivo genetic studies of Rdh10 in postnatal mouse testes and found that an RDH10 d ...[more]