Ontology highlight
ABSTRACT:
SUBMITTER: McLaughlin MF
PROVIDER: S-EPMC3548790 | biostudies-other | 2013
REPOSITORIES: biostudies-other
McLaughlin Mark F MF Woodward Jonathan J Boll Rose A RA Wall Jonathan S JS Rondinone Adam J AJ Kennel Stephen J SJ Mirzadeh Saed S Robertson J David JD
PloS one 20130118 1
Targeted radiotherapies maximize cytotoxicty to cancer cells. In vivo α-generator targeted radiotherapies can deliver multiple α particles to a receptor site dramatically amplifying the radiation dose delivered to the target. The major challenge with α-generator radiotherapies is that traditional chelating moieties are unable to sequester the radioactive daughters in the bioconjugate which is critical to minimize toxicity to healthy, non-target tissue. The recoil energy of the (225)Ac daughters ...[more]