Unknown

Dataset Information

0

Chemokine CXCL14 is associated with prognosis in patients with colorectal carcinoma after curative resection.

ABSTRACT: BACKGROUND: The chemokine CXCL14 has been reported to play an important role in the progression of many malignancies such as breast cancer and papillary thyroid carcinoma, but the role of CXCL14 in colorectal carcinoma (CRC) remains to be established. The purpose of this study was to investigate the expression pattern and significance of CXCL14 in CRC progression. METHOD: 265 colorectal carcinoma specimens and 129 matched adjacent normal colorectal mucosa specimens were collected. Expression of CXCL14 in clinical samples was examined by immunostaining. The effect of CXCL14 on colorectal carcinoma cell proliferation was measured by MTT assay, BrdU incorporation assay and colony formation assay. The impact of CXCL14 on migration and invasion of colorectal carcinoma cells was determined by transwell assay and Matrigel invasion assay, respectively. RESULTS: CXCL14 expression was significantly up-regulated in tumor tissues compared with adjacent nontumorous mucosa tissues (P?

SUBMITTER: Zeng J 

PROVIDER: S-EPMC3551837 | biostudies-other | 2013

REPOSITORIES: biostudies-other

Json Xml
altmetric image

Publications

Chemokine CXCL14 is associated with prognosis in patients with colorectal carcinoma after curative resection.

Zeng Jun J   Yang Xudan X   Cheng Lin L   Liu Rui R   Lei Yunlong Y   Dong Dandan D   Li Fanghua F   Lau Quek Choon QC   Deng Longfei L   Nice Edouard C EC   Xie Ke K   Huang Canhua C  

Journal of translational medicine 20130107

<h4>Background</h4>The chemokine CXCL14 has been reported to play an important role in the progression of many malignancies such as breast cancer and papillary thyroid carcinoma, but the role of CXCL14 in colorectal carcinoma (CRC) remains to be established. The purpose of this study was to investigate the expression pattern and significance of CXCL14 in CRC progression.<h4>Method</h4>265 colorectal carcinoma specimens and 129 matched adjacent normal colorectal mucosa specimens were collected. E  ...[more]

Similar Datasets

Unknown Post-pulmonary metastasectomy prognosis after curative resection for colorectal cancer.
| S-EPMC5482677 | biostudies-literature
Unknown High GCLC level in tumor tissues is associated with poor prognosis of hepatocellular carcinoma after curative resection.
| S-EPMC6603424 | biostudies-literature
Unknown Preoperative systemic immune-inflammation index predicts prognosis of patients with oral squamous cell carcinoma after curative resection.
| S-EPMC6299596 | biostudies-literature
Unknown High S100A9<sup>+</sup> cell density predicts a poor prognosis in hepatocellular carcinoma patients after curative resection.
| S-EPMC8266308 | biostudies-literature
Unknown Chromobox 2 Expression Predicts Prognosis After Curative Resection of Oesophageal Squamous Cell Carcinoma.
| S-EPMC7367605 | biostudies-literature
Unknown Inflammation-nutrition scope predicts prognosis of early-stage hepatocellular carcinoma after curative resection.
| S-EPMC5626267 | biostudies-literature
Unknown HBV-DNA Load-Related Peritumoral Inflammation and ALBI Scores Predict HBV Associated Hepatocellular Carcinoma Prognosis after Curative Resection.
| S-EPMC6171205 | biostudies-literature
Unknown Systemic Hepatic-Damage Index for Predicting the Prognosis of Hepatocellular Carcinoma after Curative Resection.
| S-EPMC5513961 | biostudies-literature
Unknown Downregulation of Epstein-Barr virus-induced gene 3 is associated with poor prognosis of hepatocellular carcinoma after curative resection.
| S-EPMC5934722 | biostudies-literature
Unknown High expression of 5-hydroxymethylcytosine and isocitrate dehydrogenase 2 is associated with favorable prognosis after curative resection of hepatocellular carcinoma.
| S-EPMC4081660 | biostudies-literature