Ontology highlight
ABSTRACT:
SUBMITTER: Reardon C
PROVIDER: S-EPMC3557089 | biostudies-other | 2013 Jan
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20130107 4
Appropriate control of immune responses is a critical determinant of health. Here, we show that choline acetyltransferase (ChAT) is expressed and ACh is produced by B cells and other immune cells that have an impact on innate immunity. ChAT expression occurs in mucosal-associated lymph tissue, subsequent to microbial colonization, and is reduced by antibiotic treatment. MyD88-dependent Toll-like receptor up-regulates ChAT in a transient manner. Unlike the previously described CD4(+) T-cell popul ...[more]