Ontology highlight
ABSTRACT:
SUBMITTER: van de Ven KC
PROVIDER: S-EPMC3561817 | biostudies-other | 2013 Feb
REPOSITORIES: biostudies-other
van de Ven Kim C C KC Tack Cees J CJ Heerschap Arend A van der Graaf Marinette M de Galan Bastiaan E BE
The Journal of clinical investigation 20130109 2
Patients with type 1 diabetes mellitus (T1DM) experience, on average, 2 to 3 hypoglycemic episodes per week. This study investigated the effect of hypoglycemia on cerebral glucose metabolism in patients with uncomplicated T1DM. For this purpose, hyperinsulinemic euglycemic and hypoglycemic glucose clamps were performed on separate days, using [1-13C]glucose infusion to increase plasma 13C enrichment. In vivo brain 13C magnetic resonance spectroscopy was used to measure the time course of 13C lab ...[more]