Ontology highlight
ABSTRACT:
SUBMITTER: Kumazoe M
PROVIDER: S-EPMC3561824 | biostudies-other | 2013 Feb
REPOSITORIES: biostudies-other
Kumazoe Motofumi M Sugihara Kaori K Tsukamoto Shuntaro S Huang Yuhui Y Tsurudome Yukari Y Suzuki Takashi T Suemasu Yumi Y Ueda Naoki N Yamashita Shuya S Kim Yoonhee Y Yamada Koji K Tachibana Hirofumi H
The Journal of clinical investigation 20130125 2
The 67-kDa laminin receptor (67LR) is a laminin-binding protein overexpressed in various types of cancer, including bile duct carcinoma, colorectal carcinoma, cervical cancer, and breast carcinoma. 67LR plays a vital role in growth and metastasis of tumor cells and resistance to chemotherapy. Here, we show that 67LR functions as a cancer-specific death receptor. In this cell death receptor pathway, cGMP initiated cancer-specific cell death by activating the PKCδ/acid sphingomyelinase (PKCδ/ASM) ...[more]