Ontology highlight
ABSTRACT:
SUBMITTER: Porporato PE
PROVIDER: S-EPMC3561827 | biostudies-other | 2013 Feb
REPOSITORIES: biostudies-other
Porporato Paolo E PE Filigheddu Nicoletta N Reano Simone S Ferrara Michele M Angelino Elia E Gnocchi Viola F VF Prodam Flavia F Ronchi Giulia G Fagoonee Sharmila S Fornaro Michele M Chianale Federica F Baldanzi Gianluca G Surico Nicola N Sinigaglia Fabiola F Perroteau Isabelle I Smith Roy G RG Sun Yuxiang Y Geuna Stefano S Graziani Andrea A
The Journal of clinical investigation 20130102 2
Cachexia is a wasting syndrome associated with cancer, AIDS, multiple sclerosis, and several other disease states. It is characterized by weight loss, fatigue, loss of appetite, and skeletal muscle atrophy and is associated with poor patient prognosis, making it an important treatment target. Ghrelin is a peptide hormone that stimulates growth hormone (GH) release and positive energy balance through binding to the receptor GHSR-1a. Only acylated ghrelin (AG), but not the unacylated form (UnAG), ...[more]