Comparative proteomic analysis implicates eEF2 as a novel target of PI3K? in the MDA-MB-231 metastatic breast cancer cell line.
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ABSTRACT:
SUBMITTER: Niu M
PROVIDER: S-EPMC3564858 | biostudies-other | 2013 Jan
REPOSITORIES: biostudies-other
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Comparative proteomic analysis implicates eEF2 as a novel target of PI3Kγ in the MDA-MB-231 metastatic breast cancer cell line.
Niu Meizhi M Klingler-Hoffmann Manuela M Brazzatti Julie A JA Forbes Briony B Akekawatchai Chareeporn C Hoffmann Peter P McColl Shaun R SR
Proteome science 20130115 1
<h4>Unlabelled</h4><h4>Background</h4>Cancer cell migration is fundamentally required for breast tumour invasion and metastasis. The insulin-like growth factor 1 tyrosine kinase receptor (IGF-1R) and the chemokine G-protein coupled receptor, CXCR4 have been shown to play an important role in breast cancer metastasis. Our previous study has shown that IGF-1R can transactivate CXCR4 via a physical association in the human MDA-MB-231 metastatic breast cancer cell line and that this plays a key role ...[more]
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