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Highly abundant proteins favor more stable 3D structures in yeast.

ABSTRACT: To understand the variation of protein sequences in nature, we need to reckon with evolutionary constraints that are biophysical, cellular, and ecological. Here, we show that under the global selection against protein misfolding, there exists a scaling among protein folding stability, protein cellular abundance, and effective population size. The specific scaling implies that the several-orders-of-magnitude range of protein abundances in the cell should leave imprints on extant protein structures, a prediction that is supported by our structural analysis of the yeast proteome.

SUBMITTER: Serohijos AW

PROVIDER: S-EPMC3566449 | biostudies-other | 2013 Feb

REPOSITORIES: biostudies-other

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Highly abundant proteins favor more stable 3D structures in yeast.

Serohijos Adrian W R AW Lee S Y Ryan SY Shakhnovich Eugene I EI

Biophysical journal 20130201 3

To understand the variation of protein sequences in nature, we need to reckon with evolutionary constraints that are biophysical, cellular, and ecological. Here, we show that under the global selection against protein misfolding, there exists a scaling among protein folding stability, protein cellular abundance, and effective population size. The specific scaling implies that the several-orders-of-magnitude range of protein abundances in the cell should leave imprints on extant protein structure ...[more]

PMID: 23442924

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Highly abundant proteins favor more stable 3D structures in yeast.

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Highly abundant proteins favor more stable 3D structures in yeast.

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