Ontology highlight
ABSTRACT:
SUBMITTER: Leven M
PROVIDER: S-EPMC3566766 | biostudies-other | 2013
REPOSITORIES: biostudies-other
Beilstein journal of organic chemistry 20130123
Four catalysts based on new amides of chiral 1,2-diamines and 2-sulfobenzoic acid have been developed. The alkali-metal salts of these betaine-like amides are able to form imines with enones, which are activated by Lewis acid interaction for nucleophilic attack by 4-hydroxycoumarin. The addition of 4-hydroxycoumarin to enones gives ee's up to 83% and almost quantitative yields in many cases. This novel type of catalysis provides an effective alternative to conventional primary amino catalysis we ...[more]