Ontology highlight
ABSTRACT:
SUBMITTER: Dixon KM
PROVIDER: S-EPMC3566801 | biostudies-other | 2013 Feb
REPOSITORIES: biostudies-other
Dixon K M KM Lui G Y L GY Kovacevic Z Z Zhang D D Yao M M Chen Z Z Dong Q Q Assinder S J SJ Richardson D R DR Richardson D R DR
British journal of cancer 20130103 2
<h4>Background</h4>Effective treatment of prostate cancer should be based on targeting interactions between tumour cell signalling pathways and key converging downstream effectors. Here, we determined how the tumourigenic phosphoinositide 3-kinase/protein kinase B (PI3K/AKT), tumour-suppressive phosphatase and tensin homologue deleted on chromosome 10 (PTEN) and transforming growth factor-β (TGF-β) pathways are integrated via the metastasis suppressor, N-myc downstream-regulated gene-1 (NDRG1). ...[more]