Systematic classification of vertebrate chemokines based on conserved synteny and evolutionary history.
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ABSTRACT:
SUBMITTER: Nomiyama H
PROVIDER: S-EPMC3568907 | biostudies-other | 2013 Jan
REPOSITORIES: biostudies-other
Publications
Systematic classification of vertebrate chemokines based on conserved synteny and evolutionary history.
Nomiyama Hisayuki H Osada Naoki N Yoshie Osamu O
Genes to cells : devoted to molecular & cellular mechanisms 20121112 1
The genes involved in host defences are known to undergo rapid evolution. Therefore, it is often difficult to assign orthologs in multigene families among various vertebrate species. Chemokines are a large family of small cytokines that orchestrate cell migration in health and disease. Herein, we have surveyed the genomes of 18 representative vertebrate species for chemokine genes and identified a total of 553 genes. We have determined their orthologous relationships and classified them in accor ...[more]
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