Cytomegalovirus DNA in semen and blood is associated with higher levels of proviral HIV DNA.
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ABSTRACT:
SUBMITTER: Gianella S
PROVIDER: S-EPMC3571441 | biostudies-other | 2013 Mar
REPOSITORIES: biostudies-other
Publications
Cytomegalovirus DNA in semen and blood is associated with higher levels of proviral HIV DNA.
Gianella Sara S Anderson Christy M CM Vargas Milenka V MV Richman Douglas D DD Little Susan J SJ Morris Sheldon R SR Smith Davey M DM
The Journal of infectious diseases 20121228 6
Over three-fourths of human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) have at least one herpesvirus detected in their semen, and cytomegalovirus (CMV) is the most prevalent. The presence of CMV is associated with higher T-cell immune activation and with HIV disease progression in treated and untreated individuals. In this study of 113 antiretroviral (ART)-naive HIV-infected MSM, we found that CMV replication in blood and semen was associated with higher levels of HIV ...[more]
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