Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC3571445 | biostudies-other | 2013 Mar
REPOSITORIES: biostudies-other
Yang Xiuli X Qin Jinhong J Promnares Kamoltip K Kariu Toru T Anderson John F JF Pal Utpal U
The Journal of infectious diseases 20130109 6
Borrelia burgdorferi bba57 is a conserved gene encoding a potential lipoprotein of unknown function. Here we show that bba57 is up-regulated in vivo and is required for early murine infection and potential spirochete transmission process. Although BBA57 is dispensable for late murine infection, the mutants were unable to induce disease. We show that BBA57, an outer membrane and surface-exposed antigen, is a major trigger of murine Lyme arthritis; even in cases of larger challenge inocula, which ...[more]