Ontology highlight
ABSTRACT:
SUBMITTER: Choi SY
PROVIDER: S-EPMC3575827 | biostudies-other | 2013 Feb
REPOSITORIES: biostudies-other
Nucleic acids research 20130108 4
CABIN1 acts as a negative regulator of p53 by keeping p53 in an inactive state on chromatin. Genotoxic stress causes rapid dissociation of CABIN1 and activation of p53. However, its molecular mechanism is still unknown. Here, we reveal the phosphorylation- and ubiquitination-dependent degradation of CABIN1 upon DNA damage, releasing p53 for transcriptional activation. The DNA-damage-signaling kinases, ATM and CHK2, phosphorylate CABIN1 and increase the degradation of CABIN1 protein. Knockdown or ...[more]