Ontology highlight
ABSTRACT:
SUBMITTER: Martin MJ
PROVIDER: S-EPMC3575841 | biostudies-other | 2013 Feb
REPOSITORIES: biostudies-other
Martin Maria Jose MJ Garcia-Ortiz Maria V MV Esteban Veronica V Blanco Luis L
Nucleic acids research 20121228 4
Human DNA polymerase mu (Polμ), a family X member involved in DNA repair, has both template-directed and terminal transferase (template-independent) activities. In addition to their ability to incorporate untemplated nucleotides, another similarity between Polµ and terminal deoxynucleotidyl transferase (TdT) is their promiscuity in using ribonucleotides (NTPs), whose physiological significance is presently unknown. As shown here, Polµ can use NTPs instead of deoxynucleotides (dNTPs) during non-h ...[more]