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ISLIM: a comprehensive approach to mapping and characterizing gene regulatory networks.

ABSTRACT: Mapping gene regulatory networks is a significant challenge in systems biology, yet only a few methods are currently capable of systems-level identification of transcription factors (TFs) that bind a specific regulatory element. We developed a microfluidic method for integrated systems-level interaction mapping of TF-DNA interactions, generating and interrogating an array of 423 full-length Drosophila TFs. With integrated systems-level interaction mapping, it is now possible to rapidly and quantitatively map gene regulatory networks of higher eukaryotes.

SUBMITTER: Rockel S 

PROVIDER: S-EPMC3575842 | biostudies-other | 2013 Feb

REPOSITORIES: biostudies-other

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Publications

iSLIM: a comprehensive approach to mapping and characterizing gene regulatory networks.

Rockel Sylvie S   Geertz Marcel M   Hens Korneel K   Deplancke Bart B   Maerkl Sebastian J SJ  

Nucleic acids research 20121220 4

Mapping gene regulatory networks is a significant challenge in systems biology, yet only a few methods are currently capable of systems-level identification of transcription factors (TFs) that bind a specific regulatory element. We developed a microfluidic method for integrated systems-level interaction mapping of TF-DNA interactions, generating and interrogating an array of 423 full-length Drosophila TFs. With integrated systems-level interaction mapping, it is now possible to rapidly and quant  ...[more]