Ontology highlight
ABSTRACT:
SUBMITTER: de Jesus-Gonzalez N
PROVIDER: S-EPMC3578478 | biostudies-other | 2012 Oct
REPOSITORIES: biostudies-other
de Jesus-Gonzalez Nilka N Robinson Emily E Penchev Radostin R von Mehren Margaret M Heinrich Michael C MC Tap William W Wang Qian Q Demetri George G George Suzanne S Humphreys Benjamin D BD
American journal of hypertension 20120712 10
<h4>Background</h4>Hypertension is a toxicity of antiangiogenic therapies and a possible biomarker that identifies patients with superior cancer outcomes. Understanding its mechanism will aid in treatment and could lead to the development of other biomarkers for predicting toxicity and anticancer efficacy. Recent evidence implicates nitric oxide (NO) suppression and endothelin-1 (ET-1) stimulation as potential mechanisms leading to antiangiogenic therapy-induced hypertension. The aim of this stu ...[more]