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Association between urinary markers of nucleic acid oxidation and mortality in type 2 diabetes: a population-based cohort study.

ABSTRACT: OBJECTIVE: We recently showed that RNA oxidation, estimated by urinary excretion of 8-oxo-7,8-dihydroguanosine (8-oxoGuo), independently predicted mortality in a cohort of 1,381 treatment-naive patients with newly diagnosed type 2 diabetes. In the present investigation, we analyzed urine collected 6 years after the diagnosis to assess the association between urinary markers of nucleic acid oxidation and mortality in patients with established and treated diabetes. RESEARCH DESIGN AND METHODS: We used data from the 970 patients who attended the screening for diabetes complications 6 years after the diagnosis. Cox proportional hazards regression was used to examine the relationship between urinary markers of DNA oxidation (8-oxo-7,8-dihydro-2'-deoxyguanosine [8-oxodG] [n = 938]) and RNA oxidation (8-oxoGuo [n = 936]) and mortality. RESULTS: During a median of 9.8 years of follow-up, 654 patients died. Urinary 8-oxoGuo assessed 6 years after the diagnosis was significantly associated with mortality. The multivariate-adjusted hazard ratios for all-cause and diabetes-related mortality of patients with 8-oxoGuo levels in the highest quartile compared with those in the lowest quartile were 1.86 (95% CI 1.34-2.58) and 1.72 (1.11-2.66), respectively. Conversely, 8-oxodG was not associated with mortality. In addition, we found an association between changes in 8-oxoGuo from diagnosis to 6-year follow-up and mortality, with increased risk in patients with an increase and decreased risk in patients with a decrease in 8-oxoGuo. CONCLUSIONS: The RNA oxidation marker 8-oxoGuo is an independent predictor of mortality in patients with established and treated type 2 diabetes, and changes in 8-oxoGuo during the first 6 years after diagnosis are associated with mortality.

SUBMITTER: Broedbaek K

PROVIDER: S-EPMC3579372 | biostudies-other | 2013 Mar

REPOSITORIES: biostudies-other

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Association between urinary markers of nucleic acid oxidation and mortality in type 2 diabetes: a population-based cohort study.

Broedbaek Kasper K Siersma Volkert V Henriksen Trine T Weimann Allan A Petersen Morten M Andersen Jon T JT Jimenez-Solem Espen E Jimenez-Solem Espen E Hansen Lars J LJ Henriksen Jan Erik JE Bonnema Steen J SJ de Fine Olivarius Niels N Poulsen Henrik E HE

Diabetes care 20121112 3

<h4>Objective</h4>We recently showed that RNA oxidation, estimated by urinary excretion of 8-oxo-7,8-dihydroguanosine (8-oxoGuo), independently predicted mortality in a cohort of 1,381 treatment-naive patients with newly diagnosed type 2 diabetes. In the present investigation, we analyzed urine collected 6 years after the diagnosis to assess the association between urinary markers of nucleic acid oxidation and mortality in patients with established and treated diabetes.<h4>Research design and me ...[more]

PMID: 23150279

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Association between urinary markers of nucleic acid oxidation and mortality in type 2 diabetes: a population-based cohort study.

Publications

Association between urinary markers of nucleic acid oxidation and mortality in type 2 diabetes: a population-based cohort study.

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