Ontology highlight
ABSTRACT:
SUBMITTER: Kondo T
PROVIDER: S-EPMC3581880 | biostudies-other | 2013 Feb
REPOSITORIES: biostudies-other
Kondo Takeshi T Kobayashi Junya J Saitoh Tatsuya T Maruyama Kenta K Ishii Ken J KJ Barber Glen N GN Komatsu Kenshi K Akira Shizuo S Kawai Taro T
Proceedings of the National Academy of Sciences of the United States of America 20130206 8
Double-stranded DNA (dsDNA) derived from pathogen- or host-damaged cells triggers innate immune responses when exposed to cytoplasm. However, the machinery underlying the primary recognition of intracellular dsDNA is obscure. Here we show that the DNA damage sensor, meiotic recombination 11 homolog A (MRE11), serves as a cytosolic sensor for dsDNA. Cells with a mutation of MRE11 gene derived from a patient with ataxia-telangiectasia-like disorder, and cells in which Mre11 was knocked down, had d ...[more]