Ontology highlight
ABSTRACT:
SUBMITTER: Zaiss DM
PROVIDER: S-EPMC3582723 | biostudies-other | 2013 Feb
REPOSITORIES: biostudies-other
Zaiss Dietmar M W DM van Loosdregt Jorg J Gorlani Andrea A Bekker Cornelis P J CP Gröne Andrea A Sibilia Maria M van Bergen en Henegouwen Paul M P PM Roovers Rob C RC Coffer Paul J PJ Sijts Alice J A M AJ
Immunity 20130117 2
Epidermal growth factor receptor (EGFR) is known to be critically involved in tissue development and homeostasis as well as in the pathogenesis of cancer. Here we showed that Foxp3(+) regulatory T (Treg) cells express EGFR under inflammatory conditions. Stimulation with the EGF-like growth factor Amphiregulin (AREG) markedly enhanced Treg cell function in vitro, and in a colitis and tumor vaccination model we showed that AREG was critical for efficient Treg cell function in vivo. In addition, ma ...[more]