Dataset Information

Dietary patterns and colorectal cancer recurrence and survival: a cohort study.

ABSTRACT: To examine the association between dietary patterns and colorectal cancer (CRC) survival.Cohort study.A familial CRC registry in Newfoundland.529 newly diagnosed CRC patients from Newfoundland. They were recruited from 1999 to 2003 and followed up until April 2010.Participants reported their dietary intake using a food frequency questionnaire. Dietary patterns were identified with factor analysis. Multivariable Cox proportional hazards models were employed to estimate HR and 95% CI for association of dietary patterns with CRC recurrence and death from all causes, after controlling for covariates.Disease-free survival (DFS) among CRC patients was significantly worsened among patients with a high processed meat dietary pattern (the highest vs the lowest quartile HR 1.82, 95% CI 1.07 to 3.09). No associations were observed with the prudent vegetable or the high-sugar patterns and DFS. The association between the processed meat pattern and DFS was restricted to patients diagnosed with colon cancer (the highest vs the lowest quartile: HR 2.29, 95% CI 1.19 to 4.40) whereas the relationship between overall survival (OS) and this pattern was observed among patients with colon cancer only (the highest vs the lowest quartile: HR 2.13, 95% CI 1.03 to 4.43). Potential effect modification was noted for sex (p value for interaction 0.04, HR 3.85 for women and 1.22 for men).The processed meat dietary pattern prior to diagnosis is associated with higher risk of tumour recurrence, metastasis and death among patients with CRC.

SUBMITTER: Zhu Y

PROVIDER: S-EPMC3586110 | biostudies-other | 2013

REPOSITORIES: biostudies-other

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Dietary patterns and colorectal cancer recurrence and survival: a cohort study.

Zhu Yun Y Wu Hao H Wang Peizhong Peter PP Savas Sevtap S Woodrow Jennifer J Wish Tyler T Jin Rong R Green Roger R Woods Michael M Roebothan Barbara B Buehler Sharon S Dicks Elizabeth E McLaughlin John R JR Campbell Peter T PT Parfrey Patrick S PS

BMJ open 20130207 2

<h4>Objective</h4>To examine the association between dietary patterns and colorectal cancer (CRC) survival.<h4>Design</h4>Cohort study.<h4>Setting</h4>A familial CRC registry in Newfoundland.<h4>Participants</h4>529 newly diagnosed CRC patients from Newfoundland. They were recruited from 1999 to 2003 and followed up until April 2010.<h4>Outcome measure</h4>Participants reported their dietary intake using a food frequency questionnaire. Dietary patterns were identified with factor analysis. Multi ...[more]

PMID: 23396503

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Project description:PurposeThe overarching goal of the FOCUS (biomarkers related to folate-dependent one-carbon metabolism in colorectal cancer (CRC) recurrence and survival) Consortium is to unravel the effect of folate and folate-mediated one-carbon metabolism (FOCM) biomarkers on CRC prognosis to provide clinically relevant advice on folate intake to cancer patients and define future tertiary prevention strategies.ParticipantsThe FOCUS Consortium is an international, prospective cohort of 2401 women and men above 18 years of age who were diagnosed with a primary invasive non-metastatic (stages I-III) CRC. The consortium comprises patients from Austria, two sites from the Netherlands, Germany and two sites from the USA. Patients are recruited after CRC diagnosis and followed at 6 and 12 months after enrolment. At each time point, sociodemographic data, data on health behaviour and clinical data are collected, blood samples are drawn.Findings to dateAn increased risk of cancer recurrences was observed among patients with higher compared with lower circulating folic acid concentrations. Furthermore, specific folate species within the FOCM pathway were associated with both inflammation and angiogenesis pathways among patients with CRC. In addition, higher vitamin B6 status was associated with better quality of life at 6 months post-treatment.Future plansBetter insights into the research on associations between folate and FOCM biomarkers and clinical outcomes in patients with CRC will facilitate the development of guidelines regarding folate intake in order to provide clinically relevant advice to patients with cancer, health professionals involved in patient care, and ultimately further tertiary prevention strategies in the future. The FOCUS Consortium offers an excellent infrastructure for short-term and long-term research projects and for combining additional biomarkers and data resulting from the individual cohorts within the next years, for example, microbiome data, omics and multiomics data or CT-quantified body composition data.

Dataset Information

Dietary patterns and colorectal cancer recurrence and survival: a cohort study.

Publications

Dietary patterns and colorectal cancer recurrence and survival: a cohort study.

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