Ontology highlight
ABSTRACT:
SUBMITTER: Ortega FJ
PROVIDER: S-EPMC3587805 | biostudies-other | 2013 Mar
REPOSITORIES: biostudies-other
Ortega Francisco J FJ Jolkkonen Jukka J Mahy Nicole N Rodríguez Manuel J MJ
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20121114 3
Glibenclamide is neuroprotective against cerebral ischemia in rats. We studied whether glibenclamide enhances long-term brain repair and improves behavioral recovery after stroke. Adult male Wistar rats were subjected to transient middle cerebral artery occlusion (MCAO) for 90 minutes. A low dose of glibenclamide (total 0.6 μg) was administered intravenously 6, 12, and 24 hours after reperfusion. We assessed behavioral outcome during a 30-day follow-up and animals were perfused for histological ...[more]