Ontology highlight
ABSTRACT:
SUBMITTER: Yan W
PROVIDER: S-EPMC3587810 | biostudies-other | 2013 Mar
REPOSITORIES: biostudies-other
Yan Wenjun W Fang Zongping Z Yang Qianzi Q Dong Hailong H Lu Yan Y Lei Chong C Xiong Lize L
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20130109 3
Our previous studies have shown that hyperbaric oxygen preconditioning (HBO-PC) induces tolerance to cerebral ischemia/reperfusion (I/R). This study aimed to investigate whether SirT1, a class III histone deacetylase, is involved in neuroprotection elicited by HBO-PC in animal and cell culture models of ischemia. Rats were subjected to middle cerebral artery occlusion for 120 minutes after HBO-PC (once a day for 5 days). Primary cultured cortical neurons were exposed to 2 hours of HBO-PC after 2 ...[more]