Ontology highlight
ABSTRACT:
SUBMITTER: Mojzych M
PROVIDER: S-EPMC3588826 | biostudies-other | 2012 Dec
REPOSITORIES: biostudies-other
Acta crystallographica. Section E, Structure reports online 20121103 Pt 12
The title compound, C21H16N4, obtained under standard Suzuki cross-coupling conditions, is a model compound in the synthesis and biological activity evaluation of new aza-analogues of sildenafil containing a pyrazolo-[4,3-e][1,2,4]triazine system. An N-H⋯N intra-molecular hydrogen bond involving the amino-benzene system and the 1,2,4-triazine moiety helps to establish a near coplanar orientation of the rings with a dihedral angle of 12.04 (4)°, which is believed to be necessary for the biologica ...[more]