Ontology highlight
ABSTRACT:
SUBMITTER: Sullivan BP
PROVIDER: S-EPMC3591805 | biostudies-other | 2013 Mar
REPOSITORIES: biostudies-other
Sullivan Bradley P BP Kopec Anna K AK Joshi Nikita N Cline Holly H Brown Juliette A JA Bishop Stephanie C SC Kassel Karen M KM Rockwell Cheryl C Mackman Nigel N Luyendyk James P JP
Blood 20130110 10
In this study, we characterized tissue factor (TF) expression in mouse hepatocytes (HPCs) and evaluated its role in mouse models of HPC transplantation and acetaminophen (APAP) overdose. TF expression was significantly reduced in isolated HPCs and liver homogenates from TF(flox/flox)/albumin-Cre mice (HPC(ΔTF) mice) compared with TF(flox/flox) mice (control mice). Isolated mouse HPCs expressed low levels of TF that clotted factor VII-deficient human plasma. In addition, HPC TF initiated factor X ...[more]