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Stress increases aversive prediction error signal in the ventral striatum.


ABSTRACT: From job interviews to the heat of battle, it is evident that people think and learn differently when stressed. In fact, learning under stress may have long-term consequences; stress facilitates aversive conditioning and associations learned during extreme stress may result in debilitating emotional responses in posttraumatic stress disorder. The mechanisms underpinning such stress-related associations, however, are unknown. Computational neuroscience has successfully characterized several mechanisms critical for associative learning under normative conditions. One such mechanism, the detection of a mismatch between expected and observed outcomes within the ventral striatum (i.e., "prediction errors"), is thought to be a critical precursor to the formation of new stimulus-outcome associations. An untested possibility, therefore, is that stress may affect learning via modulation of this mechanism. Here we combine a translational model of stress with a cognitive neuroimaging paradigm to demonstrate that stress significantly increases ventral striatum aversive (but not appetitive) prediction error signal. This provides a unique account of the propensity to form threat-related associations under stress with direct implications for our understanding of both normal stress and stress-related disorders.

SUBMITTER: Robinson OJ 

PROVIDER: S-EPMC3593853 | biostudies-other | 2013 Mar

REPOSITORIES: biostudies-other

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Stress increases aversive prediction error signal in the ventral striatum.

Robinson Oliver J OJ   Overstreet Cassie C   Charney Danielle R DR   Vytal Katherine K   Grillon Christian C  

Proceedings of the National Academy of Sciences of the United States of America 20130211 10


From job interviews to the heat of battle, it is evident that people think and learn differently when stressed. In fact, learning under stress may have long-term consequences; stress facilitates aversive conditioning and associations learned during extreme stress may result in debilitating emotional responses in posttraumatic stress disorder. The mechanisms underpinning such stress-related associations, however, are unknown. Computational neuroscience has successfully characterized several mecha  ...[more]

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