Ontology highlight
ABSTRACT:
SUBMITTER: Cantley L
PROVIDER: S-EPMC3594871 | biostudies-other | 2013 Mar
REPOSITORIES: biostudies-other
Cantley Leslie L Saunders Cheri C Guttenberg Marta M Candela Maria Elena ME Ohta Yoichi Y Yasuhara Rika R Kondo Naoki N Sgariglia Federica F Asai Shuji S Zhang Xianrong X Qin Ling L Hecht Jacqueline T JT Chen Di D Yamamoto Masato M Toyosawa Satoru S Dormans John P JP Esko Jeffrey D JD Yamaguchi Yu Y Iwamoto Masahiro M Pacifici Maurizio M Enomoto-Iwamoto Motomi M
The American journal of pathology 20121225 3
Osteochondromas and enchondromas are the most common tumors affecting the skeleton. Osteochondromas can occur as multiple lesions, such as those in patients with hereditary multiple exostoses. Unexpectedly, while studying the role of β-catenin in cartilage development, we found that its conditional deletion induces ectopic chondroma-like cartilage formation in mice. Postnatal ablation of β-catenin in cartilage induced lateral outgrowth of the growth plate within 2 weeks after ablation. The chond ...[more]