Functional annotation and ENU.
Ontology highlight
ABSTRACT:
SUBMITTER: Gunn TM
PROVIDER: S-EPMC3598525 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Publications
Functional annotation of every gene in the mouse genome is a herculean task that requires a multifaceted approach. Many large-scale initiatives are contributing to this undertaking. The International Knockout Mouse Consortium (IKMC) plans to mutate every protein-coding gene, using a combination of gene trapping and gene targeting in embryonic stem cells. Many other groups are performing using the chemical mutagen ethylnitrosourea (ENU) or transpon-based systems to induce mutations, screening off ...[more]
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