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The feasibility of a piecewise-linear dynamic bowtie filter.

ABSTRACT: The prepatient attenuator (or "bowtie filter") in CT is used to modulate the flux as a function of fan angle of the x-ray beam incident on the patient. Traditional, static bowtie filters are tailored only for very generic scans and for the average patient. The authors propose a design for a dynamic bowtie that can produce a time-dependent piecewise-linear attenuation profile. This dynamic bowtie may reduce dynamic range, dose or scatter, but in this work they focus on its ability to reduce dynamic range, which may be particularly important for systems employing photon-counting detectors.The dynamic bowtie is composed of a set of triangular wedges. Each wedge is independently moved in order to produce a time-dependent piecewise-linear attenuation profile. Simulations of the bowtie are conducted to estimate the dynamic range reduction in six clinical datasets. The control of the dynamic bowtie is determined by solving a convex optimization problem, and the dose is estimated using Monte Carlo techniques. Beam hardening artifacts are also simulated.The dynamic range is reduced by factors ranging from 2.4 to 27 depending on the part of the body studied. With a dynamic range minimization objective, the dose to the patient can be reduced from 6% to 33% while maintaining peak image noise. Further reduction in dose may be possible with a specific dose reduction objective. Beam hardening artifacts are suppressed with a two-pass algorithm.A dynamic bowtie producing a time-dependent, piecewise-linear attenuation profile is possible and can be used to modulate the flux of the scanner to the imaging task. Initial simulations show a large reduction in dynamic range. Several other applications are possible.

SUBMITTER: Hsieh SS

PROVIDER: S-EPMC3598818 | biostudies-other | 2013 Mar

REPOSITORIES: biostudies-other

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Project description:BackgroundMany proteins are highly modular, being assembled from globular domains and segments of natively disordered polypeptides. Linear motifs, short sequence modules functioning independently of protein tertiary structure, are most abundant in natively disordered polypeptides but are also found in accessible parts of globular domains, such as exposed loops. The prediction of novel occurrences of known linear motifs attempts the difficult task of distinguishing functional matches from stochastically occurring non-functional matches. Although functionality can only be confirmed experimentally, confidence in a putative motif is increased if a motif exhibits attributes associated with functional instances such as occurrence in the correct taxonomic range, cellular compartment, conservation in homologues and accessibility to interacting partners. Several tools now use these attributes to classify putative motifs based on confidence of functionality.ResultsCurrent methods assessing motif accessibility do not consider much of the information available, either predicting accessibility from primary sequence or regarding any motif occurring in a globular region as low confidence. We present a method considering accessibility and secondary structural context derived from experimentally solved protein structures to rectify this situation. Putatively functional motif occurrences are mapped onto a representative domain, given that a high quality reference SCOP domain structure is available for the protein itself or a close relative. Candidate motifs can then be scored for solvent-accessibility and secondary structure context. The scores are calibrated on a benchmark set of experimentally verified motif instances compared with a set of random matches. A combined score yields 3-fold enrichment for functional motifs assigned to high confidence classifications and 2.5-fold enrichment for random motifs assigned to low confidence classifications. The structure filter is implemented as a pipeline with both a graphical interface via the ELM resource http://elm.eu.org/ and through a Web Service protocol.ConclusionNew occurrences of known linear motifs require experimental validation as the bioinformatics tools currently have limited reliability. The ELM structure filter will aid users assessing candidate motifs presenting in globular structural regions. Most importantly, it will help users to decide whether to expend their valuable time and resources on experimental testing of interesting motif candidates.

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The feasibility of a piecewise-linear dynamic bowtie filter.

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