Coexpression of two closely linked avian genes for purine nucleotide synthesis from a bidirectional promoter.
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ABSTRACT:
SUBMITTER: Gavalas A
PROVIDER: S-EPMC360105 | biostudies-other | 1993 Aug
REPOSITORIES: biostudies-other
Publications
Coexpression of two closely linked avian genes for purine nucleotide synthesis from a bidirectional promoter.
Gavalas A A Dixon J E JE Brayton K A KA Zalkin H H
Molecular and cellular biology 19930801 8
Two avian genes encoding essential steps in the purine nucleotide biosynthetic pathway are transcribed divergently from a bidirectional promoter element. The bidirectional promoter, embedded in a CpG island, directs coexpression of GPAT and AIRC genes from distinct transcriptional start sites 229 bp apart. The bidirectional promoter can be divided in half, with each half retaining partial activity towards the cognate gene. GPAT and AIRC genes encode the enzymes that catalyze step 1 and steps 6 p ...[more]
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